Laparoscopic radical prostatectomy after robotic radical prostatectomy training: A matched pair analysis of a single surgeon experience

OBJECTIVE@#The authors compared the perioperative, oncological, and functional outcomes of asingle surgeon’s prior experience with robot assisted laparoscopic prostatectomy (RALP) to those oflaparoscopic radical prostatectomy (LRP) which he performed later after RALP.@*METHODS@#This was a retrospective study on patients who underwent LRP and RALP by a single surgeonwho performed a similar antegrade approach to the prostate. Patients’ clinical characteristics werecollected— then a 1:1 pairing on LRP to RALP patients with the same preoperative profile. Pairedt-test with a level of significance was set at p<0.05 using MedCalc.@*RESULTS@#One hundred cases were done from April 2011 to March 2020. Out of eighty-four with sufficientdata, twelve pairs were matched with no significant difference on age (p=0.13), BMI (p=0.26), clinicalstage (p=1.0), prostate size (p=0.46), PSA (p=0.40) and Gleason score (p=1.0). Significant differencewas noted on lymph node dissection (p=0.003), number of isolated lymph nodes (p=0.038), durationof procedure (p=0.0263), and surgical margin (p=0.0069). No significant difference on lymph nodeyield (p=0.67), blood loss (p=0.95), hospital stay duration (p=0.71), perineural invasion (p=0.894),lymphovascular invasion (p=0.4783), extracapsular extension (p=0.843), seminal vesicle involvement(p=0.4783), follow-up PSA (p=1.000) for two years, complications (p=0.09), return of continence(p=0.287) and erectile dysfunction (p=1.0).@*CONCLUSION@#A trained robotic surgeon can perform laparoscopic radical prostatectomy with comparableperioperative, oncologic, and functional outcomes.

Comparison of dialysis dose through real-time Kt/V by ultraviolet absorbance of spent dialysate, single-pool Daugirdas II, and Kt/BSA according to sex and age / Comparação da dose de diálise através do Kt/V em tempo real pela absorbância ultravioleta do dialisato gasto, Daugirdas II de pool único e Kt/BSA de acordo com sexo e idade

ABSTRACT Background: Kt/V OnLine (Kt/VOL) avoids inaccuracies associated with the estimation of urea volume distribution (V). The study aimed to compare Kt/VOL, Kt/V Daugirdas II, and Kt/BSA according to sex and age. Methods: Urea volume distribution and body surface area were obtained by Watson and Haycock formulas in 47 patients. V/BSA was considered as a conversion factor from Kt/V to Kt/BSA. Dry weight was determined before the study. Kt/VOL was obtained on DIALOG machines. Results: Pearson correlation between Kt/VOL vs Kt/VII and Kt/VOL vs Kt/BSA was significant for males (r = 0.446, P = 0.012 and r = -0.476 P = 0.007) and individuals < 65 years (0.457, P = 0.019 and -0.549 P = 0.004), but not for females and individuals ≥ 65 years. V/BSA between individuals < 65 and individuals ≥ 65 years were 18.28 ± 0.15 and 18.18 ± 0.16 P = 0.000). No agreement between Kt/VII vs Kt/BSA. Men and individuals > 65 years received a larger dialysis dose than, respectively, females and individuals < 65 years, in the comparison between Kt/VOL versus Kt/VII. V/BSA ratios among men and women were respectively 18.29 ± 0.13 and 18.12 ± 0.15 P = 0.000. Conclusions: Kt/VOL allows recognition of real-time dose regardless of sex and age.

RESUMO Introdução: O Kt/V OnLine (Kt/VOL) evita imprecisões associadas à estimativa da distribuição do volume de uréia (V). O estudo teve como objetivo comparar Kt/VOL, Kt/V Daugirdas II e Kt/BSA de acordo com sexo e idade. Métodos: A distribuição do volume de uréia e área de superfície corporal foram obtidas pelas fórmulas de Watson e Haycock em 47 pacientes. V/BSA foi considerado um fator de conversão de Kt/V para Kt/BSA. O peso seco foi determinado antes do estudo. Kt/VOL foi obtido através de máquinas DIALOG. Resultados: A correlação de Pearson entre Kt/VOL vs Kt/VII e Kt/VOL vs Kt/BSA foi significativa para os homens (r = 0,446, P = 0,012 e r = -0,476 P = 0,007) e indivíduos < 65 anos (0,457, P = 0,019 e -0,549 P = 0,004), mas não para mulheres e indivíduos ≥ 65 anos. A V/BSA entre indivíduos <65 e indivíduos ≥ 65 anos foi 18,28 ± 0,15 e 18,18 ± 0,16 P = 0,000). Sem concordância entre Kt/VII vs Kt/BSA. Homens e indivíduos > 65 anos receberam maior dose de diálise do que, mulheres e indivíduos <65 anos, respectivamente, na comparação entre Kt/VOL versus Kt/VII. As razões V/BSA entre homens e mulheres foram, respectivamente, 18,29 ± 0,13 e 18,12 ± 0,15 P = 0,000. Conclusões: Kt/VOL permite o reconhecimento da dose em tempo real, independentemente do sexo e idade.

Gender specific variation in risk factors of gallstone disease among adult patients

Background: Gallstone disease (GSD) is a common gastrointestinal disease diagnosed in patients presented with abdominal pain. The present study was aimed to find the association between demographic, personal, behavioural and dietary factors and GSD by gender among adult population for suggesting specific gender wise intervention to control GSD.Methods: Case-control study was conducted in 120 cases and same number of controls. Data was collected on a self-designed pretested “interview schedule”. To measure the strength of association OR was calculated by matched pair analysis using McNemar’s test.Results: Among 120 study subjects, 83 cases were females and 37 were males. Strength of association was found to be significantly higher for family h/o GSD in females (OR=8), physical inactivity (OR=8), waist-hip ratio (OR=4.2), calorie intake more than recommended dietary allowance (RDA) (OR=2.09), and diabetes (OR=4) as compare to males OR=3, OR=2.8, OR=2.5, OR=1.43, OR=2.33 respectively.Conclusions: Family h/o GSD, physical inactivity, high waist-hip ratio, calorie and fat intake more than RDA, protein intake less than RDA, hypertension and diabetes were found to be potential risk factors for the development of GSD in females. Consumption of smokeless tobacco, physical inactivity, non-vegetarian diet and intake of fats more than RDA were risk factors for GSD in males.

Estimated mortality rate and leading causes of death among individuals with chikungunya in 2016 and 2017 in Brazil

Abstract INTRODUCTION: In 2014, the first cases of autochthonous chikungunya (CHIK) were recorded in Brazil. Lethality associated with this disease is underestimated. Thus, this study aimed to analyze the causes of death among individuals with CHIK in Brazil. METHODS: A descriptive observational study was conducted on individuals with CHIK who died within 6 months from symptom onset. Data pairing between the Information System for Notifiable Diseases and the Mortality Information System was performed. Deaths were classified according to case confirmation criterion, mention of CHIK in the death certificates (DCs), and disease phase. The lethality rate per 1,000 cases was corrected for underreporting and was estimated according to region, sex, age, years of education, race/color, and cause groups. RESULTS: We identified 3,135 deaths (mention of CHIK in the DCs, 764 [24.4%]). In 17.6% of these cases, CHIK was the underlying cause. Most deaths occurred in the acute (38.1%) and post-acute (29.6%) phases. The corrected LR (5.7; x1,000) was 6.8 times higher than that obtained from the Information System for Notifiable Diseases (0.8). The highest corrected LRs were estimated for among individuals living in the Northeast region (6.2), men (7.4), those with low years of education and those aged <1 year (8.6), 65-79 years (20.7), and ≥80 years (75.4). CONCLUSIONS: The LR of CHIK estimates based on information system linkage help to reveal the relevance of this disease as the direct cause or as a cause associated with serious or fatal events, provide timely interventions, and increase the knowledge about this disease.

Prognostic significance of normal-sized ovary in advanced serous epithelial ovarian cancer / 부인종양

OBJECTIVE: We compared survival outcomes of advanced serous type epithelial ovarian cancer (EOC) patients with normal-sized ovaries and enlarged-ovarian tumors by propensity score matching analysis. METHODS: The medical records of EOC patients treated at Samsung Medical Center between 2002 and 2015 were reviewed retrospectively. We investigated EOC patients with high grade serous type histology and International Federation of Gynecology and Obstetrics (FIGO) stage IIIB, IIIC, or IV who underwent primary debulking surgery (PDS) and adjuvant chemotherapy to identify patients with normal-sized ovaries. Propensity score matching was performed to compare patients with normal-sized ovaries to patients with enlarged-ovarian tumors (ratio, 1:3) according to age, FIGO stage, initial cancer antigen (CA)-125 level, and residual disease status after PDS. RESULTS: Of the 419 EOC patients, 48 patients had normal-sized ovary. Patients with enlarged-ovarian tumor were younger (54.0±10.3 vs. 58.4±9.2 years, p=0.005) than those with normal-sized ovary, and there was a statistically significant difference in residual disease status between the 2 groups. In total cohort with a median follow-up period of 43 months (range, 3–164 months), inferior overall survival (OS) was shown in the normal-sized ovary group (median OS, 71.2 vs. 41.4 months; p=0.003). After propensity score matching, the group with normal-sized ovary showed inferior OS compared to the group with enlarged-ovarian tumor (median OS, 72.1 vs. 41.4 months; p=0.031). In multivariate analysis for OS, normal-sized ovary remained a significant factor. CONCLUSION: Normal-sized ovary was associated with poor OS compared with the common presentation of enlarged ovaries in EOC, independent of CA-125 level or residual disease.

Application effect of emergency medical service in patients with acute upper gastrointestinal hemorrhage / 中国基层医药

Objective To discuss the effect of emergency integrated green channel for patients with upper gastrointestinal hemorrhage. Methods From January 2014 to August 2016,182 patients with acute upper gastrointes-tinal hemorrhage were selected in the research. Eighty - four patients with acute upper gastrointestinal hemorrhage before the emergency integrated green channel established in Zhoushan Hospital were selected as control group,while 98 patients with acute upper gastrointestinal hemorrhage after the emergency integrated green channel established in Zhoushan Hospital were selected as research group. The control group received conventional emergency treatment, while the research group received emergency medical service. The average hemostasis time,mean volume of blood transfusion,average hospitalization period,average hospital cost,the operability,recurrence rate of bleeding and mortality rate were compared between the two groups. Results The average hemostasis time,average blood transfusion volume, average hospitalization time and average hospitalization expense in the study group were (4. 52 ± 1. 24)h,(352. 37 ± 17. 35)mL,(6. 02 ± 0. 89) d,(5346. 84 ± 338. 76) yuan,respectively,which in the control group were (9. 43 ± 2. 04)h,(512. 72 ± 15. 3)mL,(9. 24 ± 1. 16)d and (7012. 38 ± 422. 12)yuan,respectively,there were statistically significant differences between two groups(t = 19. 921,65. 542,21. 160,29. 517,all P < 0. 05). The operative rate, recurrence rate and mortality rate in the study group were 2. 04％ (2 / 98),3. 06％ (3 / 98) and 2. 04％ (2 / 98), respectively,which were significantly lower than those in the control group [8. 33％ (7 / 84),9. 52％ (8 / 84) and 5. 96％ (4 / 84)], the differences were statistically significant ( χ2 = 71. 202,67. 455,74. 195, all P < 0. 01). Conclusion Application of emergency medical service in patients with acute upper gastrointestinal hemorrhage not only can control bleeding effectively,decrease blood transfusion,hospitalization period and hospital cost,but also can reduce operability,recurrence rate of bleeding and mortality rate,which can serve as an emergency treatment plan applying to clinic.

Óbitos e feridos graves por acidentes de trânsito em Goiânia, Brasil - 2013: magnitude e fatores associados / Muertes y heridos graves por accidentes de tránsito en Goiânia, Brasil - 2013: magnitud y factores associados / Deaths and serious injuries due to traffic accidents in Goiânia, Brazil - 2013: the magnitude and associated factors

Objetivo: identificar a magnitude e fatores associados ao óbito e lesões graves entre vítimas de acidentes de trânsito ocorridos na área urbana de Goiânia, Brasil. Métodos: estudo transversal com linkage entre registros do Sistema de Informações sobre Mortalidade (SIM), Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS) e ocorrências de acidentes de trânsito, no período de janeiro a junho de 2013; utilizou-se a regressão de Poisson. Resultados: entre 9.795 vítimas identificadas, houve 155 óbitos e 1.225 feridos graves; ciclistas (razão de incidência [RI]=2,26; IC95% 1,19;4,30) e pedestres (RI=2,12; IC95% 1,26;3,58) tiveram maior risco de morte, enquanto o risco de lesões graves foi superior entre motociclistas (RI=2,38; IC95% 2,01;2,83), ciclistas (RI=2,35; IC95% 1,76;3,13) e pedestres (RI=2,83; IC95% 2,27;3,53). Conclusão: o estudo revelou número de óbitos e feridos graves mais próximo do real e identificou grupos vulneráveis, possível alvo para o planejamento de ações de segurança no trânsito.

Objetivo: identificar la magnitud y factores asociados a muerte y lesiones graves entre víctimas de accidentes de tránsito ocurridos en el área urbana de Goiânia, Brasil. Métodos: estudio transversal con enlace entre registros del Sistema de Información sobre Mortalidad (SIM), Sistema de Información Hospitalaria del Sistema Único de Salud (SIH / SUS), ocurrencias de accidentes de tránsito, entre enero-junio 2013; utilizamos regresión de Poisson. Resultados: entre 9.795 víctimas, hubo 155 muertes y 1.225 heridos graves; ciclistas (razón de incidencia [RI = 2,26], IC95% 1,19, 4,30) y peatones (RI = 2,12, IC95% 1,26, 3,58) tuvieron mayor riesgo de muerte, mientras que el riesgo de lesiones graves fue superior entre motociclistas (RI=2,38; IC95% 2,01;2,83), ciclistas (RI=2,35; IC95% 1,76;3,13) y peatones (RI=2,83; IC95% 2,27;3,53). Conclusión: el estudio reveló un número de muertes y heridos graves más cerca de lo real e identificó grupos vulnerables para la planificación de acciones de seguridad de tránsito.

Objective: to identify the magnitude and factors associated with death and serious injuries among victims of traffic accidents in the urban area of Goiânia, Brazil. Methods: cross-sectional study with linkage between records of the Mortality Information System (SIM) Hospital Information System of the Brazilian National Health System (SIH/SUS) and occurrences of traffic accidents, from January to June 2013; Poisson regression was used. Results: among 9,795 identified victims, there were 155 deaths and 1,225 serious injuries; cyclists (Incidence ratio [IR]=2.26; 95%CI 1.19;4.30) and pedestrians (IR=2.12; 95%CI 1.26;3.58) had an increased risk of death, while the risk of serious injuries was higher among motorcyclists (IR=2.38; 95%CI 2.01;2.83), cyclists (IR=2.35; 95%CI 1.76;3.13) and pedestrians (IR=2.83; 95%CI 2.27;3.53). Conclusion: the study revealed a number of deaths and serious injuries, closer to the real and identified vulnerable groups to plan traffic safety actions.

Drusini's and Takei's Methods for Age Estimation in Korean Adults / 대한법의학회지

Estimation of an individual's age has received considerable attention in forensic science. Several methods have been described, and abundant results have been obtained and evaluated. Among the numerous methods for dental age prediction in adults, the progressive diminution of the coronal pulp cavity and dental attrition have been primarily used. Although the reliability of age estimation methods using teeth has been demonstrated, correlation between methods has not been reported. Therefore, the aim of this study was to evaluate concurrence between Drusini's methods. We reanalyzed the age of 107 patients (64 male, 43 female) using Drusini's method. The ages had been previously estimated as ranging from 24 to 69 years using Takei's method. Our results revealed a strong correlation between the two methods (r=0.762) and suggest both methods to be suitable for application in Korean individuals younger than 50 years old. A previous study has shown Takei's and Drusini's methods to be reliable for forensic purposes. The strong correlation between the two methods in the present study suggests that it would be reasonable to use the most appropriate method for age estimation dependent on oral state.

T test as a parametric statistic / 대한마취과학회지

In statistic tests, the probability distribution of the statistics is important. When samples are drawn from population N (micro, sigma2) with a sample size of n, the distribution of the sample mean X should be a normal distribution N (micro, sigma2/n). Under the null hypothesis micro = micro0, the distribution of statistics z=X-micro0/sigma/radical(n) should be standardized as a normal distribution. When the variance of the population is not known, replacement with the sample variance s2 is possible. In this case, the statistics X-micro0/s/radical(n) follows a t distribution (n-1 degrees of freedom). An independent-group t test can be carried out for a comparison of means between two independent groups, with a paired t test for paired data. As the t test is a parametric test, samples should meet certain preconditions, such as normality, equal variances and independence.

Mahalanobis' distance and propensity score to construct a controlled matched group in a Brazilian study of health promotion and social determinants / Distância de Mahalanobis e escore de propensão para seleção de amostra pareada de controle em um estudo Brasileiro de promoção da saúde e determinantes sociais

In observational epidemiology it is usual to select a control group to study the effects of certain exposures on human health. Intervention studies are well known among epidemiologists but it is not very frequent in other areas of research. In this paper we propose the same idea of intervention studies and the use of three methods for a health promotion research control group selection: Propensity score, Mahalanobis' distance and Mahalanobis within Propensity Calipers. In the original project, "Health and Local Development: a progress review towards the millennium goals with relation to health in the Brazilian cities which develop social agendas", cities with social agendas from Brazil were matched separately by state. In the state of Paraná there are 397 cities. Of these, 34 presented social agendas implemented and active since, at least, 2004. Five variables measured in 2000 were considered for the matching: population size, human development index of income, human development index of education, percentage of literacy and vaccine coverage. As a result, among these three methods, the Mahalanobis by itself was considered the less efficient. In conclusion, the propensity, which is a very simple linear score, presented very good matched sample. However, the Mahalanobis within Calipers was the method that provided the best result.

Em epidemiologia observacional, é frequente o uso de grupos controle para avaliação do efeito de variáveis de exposição em desfechos na saúde de pessoas, porém este método não é muito utilizado em outras áreas. Este artigo propõe a aplicação da ideia de estudos de intervenção, com base em seleção de grupo controle, utilizando três métodos de seleção de amostra (escore de propensão, distância de Mahalanobis e distância de Mahalanobis dentro da margem estabelecida pelo escore de propensão) para pesquisa de promoção da saúde. No projeto “Saúde e desenvolvimento local: análise dos progressos em relação aos objetivos de desenvolvimento do milênio relacionados à saúde, nas cidades brasileiras que desenvolvem agendas sociais”, cidades com agendas sociais foram pareadas com amostra controle sem agendas sociais, para cada um dos estados do Brasil. Neste artigo foi considerado o estado do Paraná que tem 397 cidades sendo 34 com agendas sociais implementadas desde pelo menos 2004. Cinco variáveis, coletadas em 2000, foram consideradas para o pareamento: tamanho populacional, índice de desenvolvimento humano econômico e educacional, percentual de pessoas escolarizadas e cobertura vacinal. O resultado do pareamento com o uso da distância de Mahalanobis foi o que apresentou menor qualidade. Conclui-se que o método do escore de propensão, o mais simples e mais facilmente utilizado, apresentou como resultado um grupo de controle confiável. Entretanto, a distância de Mahalanobis dentro de margens do escore de propensão é o método que obteve o melhor resultado.

Relação entre plano de saúde e a realização do exame Papanicolaou: uma aplicação de escore de propensão usando um inquérito amostral complexo / Relationship between health care insurance and Papanicolaou exam: a propensity score application using a complex sample inquiry

O câncer de colo de útero é a segunda doença mais comum entre mulheres em todo o mundo. O esfregaço de Papanicolaou é um teste simples que pode detectar a doença em um estágio precoce e curável. Embora indicado para todas as mulheres adultas, a cobertura do teste é inferior a 70 por cento das mulheres brasileiras. Este estudo teve como objetivo avaliar se a posse de plano de saúde privado está associada à realização do exame de Papanicolaou. Foram analisados dados de 6.299 mulheres com 35 anos ou mais de idade, residentes no Rio de Janeiro, entrevistadas na Pesquisa Nacional por Amostra de Domicílios (PNAD) em 2003. A fim de minimizar a ocorrência de vieses, utilizamos o escore de propensão com a técnica de pareamento, levando em consideração todas as informações do desenho amostral na estimação dos escores (pesos amostrais, estratos e unidades primárias de amostragem). Uma subamostra de 2.348 mulheres foi então obtida, com covariáveis socioeconômicas e biológicas distribuídas igualmente entre os grupos com e sem cobertura de plano de saúde privado (1.174 pares). Os resultados com utilização de modelo de regressão logística mostraram que a chance de realizar o exame Papanicolaou é 26,1 por cento maior (OR=1,261; p=0,096; IC 95 por cento=[0,96; 1,66]) para mulheres com plano de saúde quando comparadas às mulheres sem cobertura de plano de saúde, no nível de significância de 10 por cento. Os resultados indicam a necessidade da extensão do rastreio periódico do câncer de colo de útero para todas as mulheres, reduzindo as desigualdades ainda presentes nos dias atuais.

Cervical uterine cancer is the second most common malignancy affecting women worldwide. Papanicolaou smear is a simple screening test that can detect the disease at an early and curable stage. Although indicated to every adult woman, Pap smear screening covers less than 70 percent of Brazilian women. This study aimed to evaluate if private health care insurance coverage was associated with Papanicolaou smear screening. We analyzed data from 6,299 women aged 35 years or older, resident in Rio de Janeiro state, who had been interviewed in the National Household Sample Survey (PNAD) in 2003. In order to minimize the occurrence of biases, we utilized the propensity score matching method, considering all information from sample design in the scores estimation (sample weights, strata and primary sampling units). A sub-sample of 2,348 women was then obtained, with socioeconomic and biological covariates equally distributed between the groups with and without private health insurance coverage (1,174 pairs). Logistic regression model was then used and the results showed that the chance of Papanicolaou smear screening is 26.1 percent higher (OR=1.261; p=0,096; CI 95 percent= [0.96;1.66]) for women with health insurance coverage when compared to women without health insurance coverage at 10 percent of significance. The results indicate the need of extending periodic cervical cancer screening for all women, reducing the inequalities still present nowadays.

Subnotificação da comorbidade tuberculose e aids: uma aplicação do método de linkage / Underreporting of the tuberculosis and AIDS comorbidity: an application of the linkage method / Subnotificación de la comorbilidad tuberculosis y sida: una aplicación del método de linkage

OBJETIVO: Analisar a subnotificação da comorbidade tuberculose (TB) e aids. MÉTODOS: Estudo de vigilância utilizando os registros do Sistema de Informação de Agravos de Notificação de Tuberculose e de aids no Brasil de 2000 a 2005. Registros de TB sem informação da presença de aids foram considerados subnotificações da comorbidade quando pareados a registros de aids que apresentassem ano de diagnóstico de aids igual ou anterior ao ano de notificação da TB, assim como os registros de um mesmo paciente cujos registros anteriores apresentavam essa informação. Criou-se um indicador: comorbidade TB-aids reconhecida, a partir dos registros de TB com a informação de presença de aids. RESULTADOS: A subnotificação de TB-aids foi de 17,7 por cento. Esse percentual variou entre estados. A incorporação dos registros subnotificados aos previamente reconhecidos elevou a proporção de TB-aids no Brasil de 6,9 por cento para 8,4 por cento. As maiores proporções de subnotificação foram observadas no Acre, Alagoas, Maranhão e Piauí (mais de 35 por cento cada) e as menores em São Paulo e Goiás (cerca de 10 por cento cada). CONCLUSÕES: A subnotificação da comorbidade TB-aids encontrada no Brasil deve deflagrar modificações no sistema de vigilância para prover informações aos programas nacionais.

OBJECTIVE: To analyze the underreporting of the tuberculosis (TB) and AIDS comorbidity. METHODS: Surveillance study using records from the Notifiable Diseases Information System - Tuberculosis and AIDS in Brazil from 2000 to 2005. Records of TB without information on the presence of Aids were considered to be underreporting of the comorbidity when paired off with AIDS records in which the year of diagnosis of AIDS was the same or previous to the year of reporting of TB, as well as records from the same patient whose previous records had this information. An indicator was created: recognized TB-AIDS comorbidity, based on the TB records that had information on the presence of AIDS. RESULTS: The underreporting of TB-AIDS was 17.7 percent. This percentage varied between states. The incorporation of the underreported records into the previously recognized ones increased the proportion of TB-AIDS in Brazil from 6.9 percent to 8.4 percent. The highest proportions of underreporting were noted in Acre (Northern), Alagoas, Maranhão and Piauí (Northeastern) (more than 35 percent each) and the lowest in São Paulo (Southeastern) and Goiás (Central-western) (around 10 percent each). CONCLUSIONS: The underreporting of the TB-AIDS comorbidity found in Brazil will probably trigger modifications in the surveillance system in order to provide information for the national programs.

OBJETIVO: Analizar la subnotificación de la comorbilidad tuberculosis (TB) y sida. MÉTODOS: Estudio de vigilancia utilizando los registros del Sistema de Información de Agravios de Notificación de Tuberculosis y de sida en Brasil de 2000 a 2005. Registros de TB sin información de la presencia de sida fueron consideradas subnotificaciones de la comorbilidad cuando se parearon a registros de sida que presentaron año de diagnóstico de sida igual o anterior al año de notificación de la TB, así como los registros de un mismo paciente cuyos registros anteriores presentaban esa información. Se creó un indicador: comorbilidad TB-sida reconocida, a partir de los registros de TB con la información de presencia de sida. RESULTADOS: La subnotificación de TB-sida fue de 17,7 por ciento. Este porcentaje varió entre estados. La incorporación de los registros subnotificados a los previamente reconocidos elevó la proporción de TB-sida en Brasil de 6,9 por ciento a 8,4 por ciento. Las mayores proporciones de subnotificación fueron observadas en Acre, Alagoas, Maranhao y Piauí (más de 35 por ciento en cada uno) y las menores en Sao Paulo y Goiás (cerca de 10 por ciento en cada uno). CONCLUSIONES: La subnotificación de la comorbilidad TB-sida encontrada en Brasil debe deflagrar modificaciones en el sistema de vigilancia para proveer informaciones a los programas nacionales.